SRP-dependent cotranslational protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the SRP-dependent cotranslational protein targeting to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STT3A, TRAM1, and RPN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SRP-dependent cotranslational protein targeting to membrane activity versus STT3A in BRCA (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STT3A →	+0.785	+0.251	<.001	<.001	3	9
BRCA	TRAM1 →	+0.665	+0.290	<.001	<.001	3	9
BRCA	RPN2 →	+0.505	+0.236	<.001	<.001	3	8
BRCA	ATP13A1 →	+0.570	+0.225	<.001	<.001	3	8
BRCA	SPCS1 →	+0.650	+0.238	<.001	<.001	3	8
BRCA	SPCS2 →	+0.922	+0.301	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006614 vs STT3A — BRCA

Explore this scatter interactively →