SRP-dependent cotranslational protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the SRP-dependent cotranslational protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INAFM1, SEPTIN3, and CCRL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INAFM1 grouped by SRP-dependent cotranslational protein targeting to membrane-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	INAFM1 →	-1.159	-0.410	<.001	<.001	3	4
BREAST	SEPTIN3 →	-1.435	-0.282	.005	.003	3	4
PANCREAS	CCRL2 →	+2.205	+0.457	<.001	.001	3	4
OVARY	GALNT7 →	+1.520	+0.303	.002	.003	3	3
OVARY	ASAP3 →	-1.361	-0.250	<.001	.002	3	3
CNS	ALKBH7 →	-0.414	-0.489	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INAFM1 by SRP-dependent cotranslational protein targeting to membrane activity — CNS

Explore this box plot interactively →