Protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Protein targeting to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WNK2_S1862, TPPP_S160, and MAP1A_S1776, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein targeting to membrane activity versus WNK2_S1862 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WNK2_S1862 →	+0.858	+0.022	<.001	.001	3	5
LSCC	TPPP_S160 →	+0.811	+0.028	.004	<.001	3	5
LSCC	MAP1A_S1776 →	+0.456	+0.022	.004	.005	3	5
LSCC	PFN2 →	+0.500	+0.027	.001	<.001	3	5
GBM	RPL6 →	-0.653	-0.052	<.001	<.001	3	4
GBM	RPS5 →	-0.217	-0.043	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006612 vs WNK2_S1862 — LUAD

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