Protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGTA1, LINC01801, and N4BP2L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein targeting to membrane activity versus GGTA1 in COAD (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GGTA1 →	-0.475	-0.179	.007	.001	3	4
CCRCC	LINC01801 →	-0.492	-0.181	.009	.001	3	4
COAD	N4BP2L1 →	-0.643	-0.179	.001	<.001	3	4
COAD	NHLRC3 →	-0.322	-0.147	<.001	<.001	3	4
PDAC	CALCOCO1 →	-0.267	-0.217	<.001	<.001	3	4
PDAC	CNTN4 →	-0.383	-0.162	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006612 vs GGTA1 — COAD

Explore this scatter interactively →