Protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOLA2, TMEM107, and METAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BOLA2 grouped by Protein targeting to membrane-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BOLA2 →	-0.819	-0.199	.001	.003	2	5
LIVER	TMEM107 →	+1.123	+0.238	.001	.005	3	4
LIVER	METAP2 →	-0.581	-0.240	.002	.005	3	4
LIVER	UBE2E2 →	+1.280	+0.238	.006	.005	3	4
LIVER	ZBTB25 →	+0.816	+0.243	<.001	.004	3	4
CNS	CXXC1 →	-0.613	-0.199	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BOLA2 by Protein targeting to membrane activity — BLOOD_Leukemia

Explore this box plot interactively →