Protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Protein targeting to membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H1, DTX1, and SHISA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P3H1 grouped by Protein targeting to membrane-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	P3H1 →	+0.148	+0.084	.006	.009	3	4
LUNG_SCLC	DTX1 →	+0.309	+0.067	.002	.002	3	4
LARGE_INTESTINE	SHISA2 →	-0.143	-0.067	<.001	<.001	3	4
KIDNEY	FAS →	-0.317	-0.065	.007	.001	2	5
LUNG_NSCLC_LUSC	LCAT →	+0.263	+0.055	.002	.007	3	4
CNS	NXF3 →	-0.275	-0.054	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P3H1 by Protein targeting to membrane activity — LUNG_SCLC

Explore this box plot interactively →