Protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNDC5, TMED9, and TUBG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein targeting to membrane activity versus TXNDC5 in URINARY_TRACT (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TXNDC5 →	+0.909	+0.234	.002	<.001	3	5
CNS	TMED9 →	+1.018	+0.189	.002	.001	3	5
SKIN	TUBG1 →	+0.530	+0.126	<.001	<.001	3	5
URINARY_TRACT	ATP8B3 →	+2.408	+0.301	<.001	.002	3	4
URINARY_TRACT	HSPA13 →	+1.350	+0.297	.003	.004	2	5
URINARY_TRACT	SYT1 →	-1.542	-0.275	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006612 vs TXNDC5 — URINARY_TRACT

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