Protein export from nucleus

Across TCGA patient cohorts, RNA activity of the Protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATM, CHD2, and ZBTB37, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein export from nucleus activity versus ATM in UVM (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ATM →	+1.695	+0.037	<.001	<.001	3	34
SCLC	CHD2 →	+1.054	+0.087	<.001	<.001	3	34
UVM	ZBTB37 →	+1.053	+0.039	<.001	<.001	3	34
UVM	FNBP4 →	+1.608	+0.037	<.001	<.001	3	33
UVM	MED23 →	+1.131	+0.031	<.001	<.001	3	33
UVM	XRN1 →	+1.428	+0.038	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006611 vs ATM — UVM

Explore this scatter interactively →