Protein export from nucleus

Across TCGA patient cohorts, RNA activity of the Protein export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL26, and RPS16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein export from nucleus activity versus RPL5 in OV (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.164	-0.029	.005	.005	3	5
LSCC	RPL26 →	-0.512	-0.043	<.001	<.001	3	5
CCRCC	RPS16 →	-0.196	-0.029	<.001	<.001	3	5
CCRCC	EEF2_T57 →	-0.289	-0.027	<.001	<.001	3	5
BRCA	YME1L1 →	-0.251	-0.024	.004	<.001	3	5
COAD	TOR1A →	+0.172	+0.014	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006611 vs RPL5 — OV

Explore this scatter interactively →