Phosphagen metabolic process

pathway activity — cross-omics
GO:0006599Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Phosphagen metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RUFY2, CTSZ, and CYRIB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMRUFY2 →-0.202-0.114.004<.00135
LSCCCTSZ →-0.343-0.108<.001<.00135
CCRCCCYRIB →-0.266-0.124.006.00135
LSCCLPXN →-0.532-0.140<.001<.00135
CCRCCARHGAP9 →-0.402-0.132<.001<.00135
LSCCERBIN_S872 →+0.445+0.127.004<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration