Phosphagen metabolic process

pathway activity — cross-omics
GO:0006599Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Phosphagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AATK, CKB, and GAS7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADAATK →+0.523+0.740.002.00534
LUADCKB →+1.178+0.765<.001<.00134
UCECGAS7 →+0.955+0.719<.001<.00133
BRCAECM2 →+1.261+0.500.005.00133
CCRCCMYH11 →+1.060+0.730.001.00133
BRCAABCA8 →+0.876+0.336.007.00633
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration