Polyamine metabolic process

Across TCGA patient cohorts, RNA activity of the Polyamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3BP4_S246, CD47, and AKAP12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine metabolic process activity versus SH3BP4_S246 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SH3BP4_S246 →	+0.377	+0.054	.001	<.001	3	5
UCEC	CD47 →	-0.518	-0.066	<.001	<.001	3	5
GBM	AKAP12 →	+0.553	+0.051	<.001	<.001	3	5
HNSC	LAMC1 →	+0.391	+0.052	.001	.004	3	5
HNSC	NID1 →	+0.413	+0.046	.001	.001	3	5
UCEC	TAP1 →	-0.462	-0.057	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006595 vs SH3BP4_S246 — LUAD

Explore this scatter interactively →