Polyamine metabolic process

Across TCGA patient cohorts, RNA activity of the Polyamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A35, RPL36AP26, and USP9X, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine metabolic process activity versus SLC25A35 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC25A35 →	+0.758	+0.152	.003	.004	3	4
HNSC	RPL36AP26 →	+0.449	+0.102	.005	.007	3	4
CCRCC	USP9X →	-0.246	-0.181	.001	<.001	3	4
PDAC	DSE →	-0.350	-0.135	.002	.001	3	3
PDAC	WIPF1 →	-0.288	-0.120	.005	.002	3	3
PDAC	PRRX1 →	-0.510	-0.128	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006595 vs SLC25A35 — HNSC

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