Polyamine metabolic process

Across TCGA cell cohorts, RNA activity of the Polyamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMS, SMPD2, and LAMA5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine metabolic process activity versus SMS in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMS →	+1.460	+0.491	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	SMPD2 →	+0.841	+1.551	.008	<.001	3	6
BLOOD_Myeloma	LAMA5 →	-1.480	-0.097	.003	.004	3	5
OVARY	CDRT1 →	-0.956	-0.848	.002	.002	3	5
LARGE_INTESTINE	COX11 →	+0.821	+0.844	.001	.006	2	6
BLOOD_Leukemia	ACOT7 →	+1.023	+0.173	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006595 vs SMS — BREAST

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