Thyroid hormone generation

Across TCGA patient cohorts, RNA activity of the Thyroid hormone generation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSIP1, HDAC2, and CDC5L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone generation activity versus PSIP1 in LSCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSIP1 →	-0.521	-0.066	.002	<.001	3	5
GBM	HDAC2 →	-0.206	-0.042	.003	.004	3	5
BRCA	CDC5L →	-0.186	-0.070	<.001	<.001	3	4
BRCA	CPSF4 →	-0.237	-0.062	<.001	<.001	3	4
OV	FAM50A →	-0.346	-0.048	.003	.006	3	4
LUAD	GPKOW →	-0.117	-0.054	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006590 vs PSIP1 — LSCC

Explore this scatter interactively →