Thyroid hormone generation

Across TCGA patient cohorts, RNA activity of the Thyroid hormone generation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC88A, LINC02679, and RNU7-195P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone generation activity versus CCDC88A in HNSC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCDC88A →	-0.352	-0.515	<.001	.001	3	3
HNSC	LINC02679 →	-0.299	-0.463	.005	.005	3	3
COAD	RNU7-195P →	+0.230	+0.644	.005	.008	3	3
COAD	PSME2P5 →	+0.057	+0.793	<.001	<.001	3	3
CCRCC	WIPF2 →	+0.251	+0.252	.004	.007	3	3
LSCC	FAM83H →	+0.473	+0.414	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006590 vs CCDC88A — HNSC

Explore this scatter interactively →