Thyroid hormone generation

Across TCGA cell cohorts, RNA activity of the Thyroid hormone generation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNAR2, ZDHHC24, and SSC5D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFNAR2 grouped by Thyroid hormone generation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IFNAR2 →	-1.687	-1.575	.001	<.001	3	4
SOFT_TISSUE	ZDHHC24 →	-0.923	-1.533	.003	.008	3	4
CNS	SSC5D →	-2.145	-1.056	.006	.003	3	4
CNS	RALA →	-0.547	-1.008	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PLXNB3 →	-1.011	-1.324	.003	.002	3	4
LUNG_SCLC	PHACTR4 →	-0.613	-0.564	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFNAR2 by Thyroid hormone generation activity — URINARY_TRACT

Explore this box plot interactively →