Melanin metabolic process

Across TCGA patient cohorts, RNA activity of the Melanin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM28, STRBP, and TBC1D2B_S957, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanin metabolic process activity versus TRIM28 in GBM (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM28 →	-0.379	-0.051	<.001	<.001	3	6
GBM	STRBP →	-0.473	-0.059	<.001	<.001	3	5
UCEC	TBC1D2B_S957 →	+0.230	+0.054	.008	<.001	3	5
GBM	DHX9 →	-0.352	-0.065	<.001	<.001	3	5
GBM	SRSF10 →	-0.343	-0.065	<.001	.001	3	5
GBM	ATG7 →	+0.286	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006582 vs TRIM28 — GBM

Explore this scatter interactively →