Melanin metabolic process

Across TCGA cell cohorts, RNA activity of the Melanin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP2, C1orf109, and GPR137C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP2 grouped by Melanin metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IGFBP2 →	+2.951	+0.872	.003	.007	3	4
LIVER	C1orf109 →	+0.686	+1.779	.003	<.001	2	5
BLOOD_Lymphoma	GPR137C →	+1.509	+1.955	.001	<.001	3	4
BLOOD_Myeloma	TENT4B →	+0.896	+1.449	<.001	<.001	3	4
BLOOD_Leukemia	FBXO43 →	+0.948	+1.013	.002	<.001	3	4
BLOOD_Leukemia	CYB5D1 →	+1.019	+1.275	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP2 by Melanin metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →