Melanin metabolic process

Across TCGA cell cohorts, RNA activity of the Melanin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMSD, YY2, and OR1D5, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMSD grouped by Melanin metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMSD →	-0.232	-0.635	.002	.003	3	1
SKIN	YY2 →	-0.323	-0.552	.009	.006	3	1
SKIN	OR1D5 →	-0.285	-0.636	.001	.002	3	1
SKIN	APOC4 →	+0.365	+0.507	<.001	.005	3	1
SKIN	PSMD7 →	-0.187	-0.552	.006	.006	3	1
SKIN	SMG9 →	-0.436	-0.765	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMSD by Melanin metabolic process activity — SKIN

Explore this box plot interactively →