Amino-acid betaine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Amino-acid betaine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH7A1, ITGA5, and TMLHE, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine biosynthetic process activity versus ALDH7A1 in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALDH7A1 →	+0.636	+0.091	<.001	<.001	3	9
OV	ITGA5 →	-0.417	-0.041	<.001	.003	3	6
OV	TMLHE →	+0.548	+0.059	<.001	<.001	3	5
GBM	COLGALT1 →	-0.537	-0.064	<.001	<.001	3	5
CCRCC	DDAH1 →	+0.486	+0.088	<.001	<.001	3	5
CCRCC	ACTR2 →	-0.083	-0.048	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006578 vs ALDH7A1 — HNSC

Explore this scatter interactively →