Amino-acid betaine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Amino-acid betaine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSKIP, CAPZA1, and SGPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine biosynthetic process activity versus GSKIP in COAD (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GSKIP →	-0.680	-0.125	<.001	<.001	3	5
COAD	CAPZA1 →	-0.574	-0.153	<.001	<.001	3	4
OV	SGPP1 →	-0.579	-0.135	.009	.007	3	4
OV	MPHOSPH6 →	-0.652	-0.156	.001	<.001	3	4
CCRCC	HMGN1 →	-0.212	-0.116	.003	<.001	3	4
UCEC	ACSL5 →	+0.838	+0.128	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006578 vs GSKIP — COAD

Explore this scatter interactively →