Amino-acid betaine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Amino-acid betaine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH9A1, ALG5, and G3BP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine biosynthetic process activity versus ALDH9A1 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ALDH9A1 →	+0.779	+0.233	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	ALG5 →	+1.170	+0.274	.001	<.001	3	5
OESOPHAGUS	G3BP2 →	+0.676	+0.235	.005	.008	3	5
OESOPHAGUS	DLAT →	+0.585	+0.214	.003	<.001	3	4
OESOPHAGUS	KCTD6 →	+1.257	+0.318	.004	.003	3	4
OESOPHAGUS	LANCL1 →	+1.072	+0.256	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006578 vs ALDH9A1 — OVARY

Explore this scatter interactively →