Amino-acid betaine metabolic process

Across TCGA patient cohorts, RNA activity of the Amino-acid betaine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH7A1, IFT140, and ITPRID2_S1134, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine metabolic process activity versus ALDH7A1 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALDH7A1 →	+0.631	+0.045	<.001	<.001	3	7
CCRCC	IFT140 →	+0.223	+0.101	<.001	<.001	3	6
HNSC	ITPRID2_S1134 →	+0.784	+0.079	<.001	<.001	3	6
LUAD	ACTR2 →	-0.106	-0.059	.008	.002	3	6
LSCC	STARD10 →	+0.208	+0.030	.004	.003	3	5
LSCC	WDR35 →	+0.245	+0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006577 vs ALDH7A1 — LSCC

Explore this scatter interactively →