Amino-acid betaine metabolic process

Across TCGA patient cohorts, RNA activity of the Amino-acid betaine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSDE1, CCDC141, and FAM20B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine metabolic process activity versus CSDE1 in COAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CSDE1 →	-0.376	-0.118	.003	.004	3	4
PDAC	CCDC141 →	+0.479	+0.109	<.001	.001	3	4
LSCC	FAM20B →	-0.521	-0.097	<.001	.002	3	4
COAD	TOR1AIP2 →	-0.570	-0.119	<.001	<.001	3	4
HNSC	ITPR2 →	+0.575	+0.175	<.001	<.001	3	4
COAD	HMGN1P38 →	-0.547	-0.090	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006577 vs CSDE1 — COAD

Explore this scatter interactively →