Amino-acid betaine metabolic process

Across TCGA cell cohorts, RNA activity of the Amino-acid betaine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REXO4, DDX31, and MIA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, REXO4 grouped by Amino-acid betaine metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	REXO4 →	-0.877	-1.278	.005	.003	3	4
PANCREAS	DDX31 →	-0.640	-1.176	<.001	<.001	3	4
STOMACH	MIA3 →	+0.876	+1.363	.002	.007	3	3
URINARY_TRACT	SQSTM1 →	+1.586	+1.609	.002	<.001	3	3
SOFT_TISSUE	FRMD4A →	+3.269	+1.646	<.001	<.001	3	3
LUNG_NSCLC_LUSC	PYCR3 →	-1.338	-1.422	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

REXO4 by Amino-acid betaine metabolic process activity — LUNG_SCLC

Explore this box plot interactively →