Amino-acid betaine metabolic process

Across TCGA cell cohorts, RNA activity of the Amino-acid betaine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROCK2, SRP9, and UGP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine metabolic process activity versus ROCK2 in BLOOD_Lymphoma (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ROCK2 →	+0.758	+0.241	.006	.006	2	6
OESOPHAGUS	SRP9 →	+0.777	+0.221	.006	.001	3	5
BONE	UGP2 →	+1.481	+0.262	.006	.007	3	4
OVARY	CPT1A →	+1.763	+0.195	.002	.006	2	5
OVARY	ARF3 →	+0.697	+0.317	<.001	<.001	3	4
BLOOD_Leukemia	ATP6AP2 →	+0.742	+0.454	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006577 vs ROCK2 — BLOOD_Lymphoma

Explore this scatter interactively →