Biogenic amine metabolic process

Across TCGA patient cohorts, RNA activity of the Biogenic amine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, SF3B2, and EHMT2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biogenic amine metabolic process activity versus SF3B3 in LSCC (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SF3B3 →	-0.230	-0.052	<.001	<.001	3	9
GBM	SF3B2 →	-0.205	-0.035	<.001	<.001	3	8
LSCC	EHMT2 →	-0.286	-0.047	<.001	<.001	3	8
LSCC	MPHOSPH10 →	-0.473	-0.047	<.001	<.001	3	8
GBM	SF3A1 →	-0.248	-0.036	<.001	<.001	3	7
GBM	SNRPB2 →	-0.328	-0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006576 vs SF3B3 — LSCC

Explore this scatter interactively →