Biogenic amine metabolic process

Across TCGA cell cohorts, RNA activity of the Biogenic amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRTFB, IKZF2, and PUM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biogenic amine metabolic process activity versus MRTFB in BLOOD_Myeloma (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MRTFB →	-1.067	-0.119	.004	.003	3	10
SKIN	IKZF2 →	-0.691	-0.090	<.001	<.001	3	10
BLOOD_Myeloma	PUM2 →	-0.546	-0.092	.001	<.001	3	9
OESOPHAGUS	NOP9 →	-1.140	-0.098	.002	.004	3	9
LARGE_INTESTINE	PPP3CA →	-1.032	-0.122	<.001	<.001	3	9
LARGE_INTESTINE	CACUL1 →	-0.744	-0.117	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006576 vs MRTFB — BLOOD_Myeloma

Explore this scatter interactively →