Cellular modified amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Cellular modified amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHA7, BCL2L15, and CEP170, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular modified amino acid metabolic process activity versus PLEKHA7 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLEKHA7 →	+0.472	+0.029	<.001	.002	3	6
LUAD	BCL2L15 →	+0.688	+0.022	<.001	.001	3	5
LSCC	CEP170 →	-0.229	-0.025	<.001	<.001	3	5
PDAC	HSDL2 →	+0.414	+0.032	<.001	<.001	3	5
PDAC	MAOA →	+0.551	+0.035	<.001	<.001	3	5
GBM	ARHGEF2 →	-0.254	-0.024	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006575 vs PLEKHA7 — HNSC

Explore this scatter interactively →