Cellular modified amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Cellular modified amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4E, CCDC80, and INTS10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular modified amino acid metabolic process activity versus EIF4E in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EIF4E →	+1.111	+0.181	.003	.001	3	6
BREAST	CCDC80 →	-3.239	-0.291	<.001	.002	3	6
STOMACH	INTS10 →	+0.888	+0.342	.004	.008	3	6
STOMACH	FN1 →	-5.441	-0.352	.003	.003	3	6
UPPER_AERODIGESTIVE_TRACT	SUCLA2 →	+1.175	+0.204	<.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	IDH3A →	+1.161	+0.222	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006575 vs EIF4E — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →