Valine metabolic process

Across TCGA patient cohorts, RNA activity of the Valine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAT2, JPT1, and SELENBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Valine metabolic process activity versus BCAT2 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCAT2 →	+0.302	+0.062	<.001	<.001	3	7
GBM	JPT1 →	-0.372	-0.063	<.001	<.001	3	7
LSCC	SELENBP1 →	+0.588	+0.088	<.001	<.001	3	5
BRCA	ACOT7 →	-0.449	-0.051	.001	.002	3	5
BRCA	CDK1 →	-0.728	-0.062	<.001	<.001	3	5
GBM	CGNL1 →	+0.330	+0.066	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006573 vs BCAT2 — GBM

Explore this scatter interactively →