Valine metabolic process

Across TCGA cell cohorts, RNA activity of the Valine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT5B, PIF1, and ZSCAN30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNT5B grouped by Valine metabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	WNT5B →	-2.695	-1.248	<.001	.003	3	4
OVARY	PIF1 →	+0.717	+0.719	.005	.003	3	4
OVARY	ZSCAN30 →	+0.897	+1.041	.003	<.001	3	4
BLOOD_Leukemia	MAPKBP1 →	+0.987	+1.207	.003	<.001	3	4
BLOOD_Leukemia	RFX3 →	+1.055	+1.364	.003	.001	3	4
BLOOD_Myeloma	CREB3L4 →	+1.183	+1.248	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNT5B by Valine metabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →