Valine metabolic process

Across TCGA cell cohorts, RNA activity of the Valine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, FAAH2, and TMC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Valine metabolic process activity versus TJP3 in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TJP3 →	+2.650	+0.439	<.001	.001	3	7
OVARY	FAAH2 →	+1.988	+0.418	.001	.001	3	7
OVARY	TMC4 →	+2.955	+0.327	.002	.002	3	6
OVARY	SELENOP →	+3.998	+0.440	.001	.001	3	6
OVARY	RASSF7 →	+1.084	+0.312	.003	.002	3	6
URINARY_TRACT	THEM6 →	+1.980	+0.497	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006573 vs TJP3 — URINARY_TRACT

Explore this scatter interactively →