Tyrosine catabolic process

Across TCGA patient cohorts, RNA activity of the Tyrosine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HGD, PKM, and TIAM1_S231, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tyrosine catabolic process activity versus HGD in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HGD →	+2.451	+0.135	<.001	<.001	3	6
GBM	PKM →	+0.356	+0.110	<.001	<.001	3	6
CCRCC	TIAM1_S231 →	+0.588	+0.092	.003	.002	3	5
BRCA	GLA →	+0.420	+0.056	<.001	.003	3	5
CCRCC	GSR →	+0.186	+0.065	.006	.005	3	5
GBM	ATG7 →	+0.150	+0.071	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006572 vs HGD — LSCC

Explore this scatter interactively →