Tyrosine catabolic process

Across TCGA cell cohorts, RNA activity of the Tyrosine catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMIGO2, CAPZA2, and SERPINF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMIGO2 grouped by Tyrosine catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AMIGO2 →	+0.223	+1.939	.008	<.001	3	4
LARGE_INTESTINE	CAPZA2 →	-0.156	-0.831	.002	<.001	3	4
BLOOD_Lymphoma	SERPINF1 →	-0.351	-0.219	.002	.007	3	3
LUNG_SCLC	PNPLA5 →	-0.224	-1.746	.003	<.001	3	3
LUNG_SCLC	GMFG →	-0.248	-1.664	.005	<.001	3	3
LUNG_SCLC	PRRG4 →	-0.196	-1.465	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMIGO2 by Tyrosine catabolic process activity — URINARY_TRACT

Explore this box plot interactively →