Tyrosine metabolic process

Across TCGA patient cohorts, RNA activity of the Tyrosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XXYLT1, PDPN, and TTK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tyrosine metabolic process activity versus XXYLT1 in OV (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XXYLT1 →	-0.553	-0.134	.006	.002	3	5
LSCC	PDPN →	-0.672	-0.148	<.001	.001	3	4
PDAC	TTK →	-0.474	-0.151	.005	.003	3	4
PDAC	STMN1 →	-0.473	-0.175	<.001	<.001	3	4
PDAC	SACS →	-0.478	-0.164	<.001	.002	3	4
PDAC	SPHK1 →	-0.603	-0.151	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006570 vs XXYLT1 — OV

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