Tyrosine metabolic process

Across TCGA cell cohorts, RNA activity of the Tyrosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSTPIP2, CORO1B, and RAB40A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSTPIP2 grouped by Tyrosine metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PSTPIP2 →	-1.338	-1.073	.007	.004	3	3
KIDNEY	CORO1B →	-0.693	-1.144	.004	.007	3	3
BLOOD_Myeloma	RAB40A →	-0.559	-1.205	.003	.001	3	3
CNS	FBXO41 →	+0.673	+1.001	.001	<.001	3	3
CNS	ICA1 →	+1.242	+0.996	.005	.001	3	3
OVARY	PLAGL2 →	+0.850	+0.978	.002	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSTPIP2 by Tyrosine metabolic process activity — KIDNEY

Explore this box plot interactively →