Tryptophan catabolic process

Across TCGA cell cohorts, RNA activity of the Tryptophan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPHS1, GRAMD2B, and STING1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEPHS1 grouped by Tryptophan catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SEPHS1 →	+0.621	+1.009	.001	.009	3	4
CNS	GRAMD2B →	+1.666	+0.833	<.001	.004	3	3
CNS	STING1 →	+1.759	+0.690	.004	.004	2	4
BREAST	SLC9A6 →	+1.796	+1.210	<.001	<.001	3	3
CNS	NANS →	+0.600	+0.558	.008	.008	3	3
KIDNEY	CNRIP1 →	+2.322	+1.178	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEPHS1 by Tryptophan catabolic process activity — KIDNEY

Explore this box plot interactively →