Tryptophan metabolic process

Across TCGA patient cohorts, RNA activity of the Tryptophan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SP110_S380, TYMP, and CD48, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan metabolic process activity versus SP110_S380 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SP110_S380 →	+0.676	+0.094	<.001	<.001	3	10
COAD	TYMP →	+0.559	+0.043	<.001	.001	3	10
OV	CD48 →	+1.070	+0.060	<.001	.001	3	10
GBM	IFI35 →	+0.476	+0.079	<.001	<.001	3	10
GBM	ITGB2 →	+0.839	+0.109	<.001	<.001	3	10
COAD	NMI →	+0.438	+0.036	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006568 vs SP110_S380 — LSCC

Explore this scatter interactively →