Tryptophan metabolic process

Across TCGA cell cohorts, RNA activity of the Tryptophan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are R3HDM1, QPRT, and VDR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan metabolic process activity versus R3HDM1 in OESOPHAGUS (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	R3HDM1 →	+0.704	+1.189	.007	.003	3	5
LARGE_INTESTINE	QPRT →	+2.251	+1.011	.001	<.001	3	5
LIVER	VDR →	-2.290	-1.393	.006	.008	3	5
PANCREAS	ABHD11 →	-2.437	-1.533	.002	<.001	3	5
BLOOD_Lymphoma	RNF43 →	+1.697	+1.255	.009	.005	3	4
SKIN	PRMT7 →	+0.589	+1.090	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006568 vs R3HDM1 — OESOPHAGUS

Explore this scatter interactively →