L-serine catabolic process

Across TCGA patient cohorts, RNA activity of the L-serine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDS, POMK, and DHX30, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine catabolic process activity versus SDS in COAD (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SDS →	+1.438	+0.092	<.001	<.001	3	8
UCEC	POMK →	-0.345	-0.087	<.001	<.001	3	7
LSCC	DHX30 →	-0.247	-0.086	<.001	<.001	3	6
HNSC	NADK →	+0.370	+0.082	<.001	.002	3	6
LSCC	NELFCD →	-0.247	-0.079	.001	<.001	3	6
COAD	BTK →	+0.623	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006565 vs SDS — COAD

Explore this scatter interactively →