L-serine metabolic process

Across TCGA patient cohorts, RNA activity of the L-serine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASNS, PHGDH, and PSAT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine metabolic process activity versus ASNS in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.635	+0.060	<.001	<.001	3	8
HNSC	PHGDH →	+0.791	+0.102	<.001	<.001	3	8
BRCA	PSAT1 →	+0.936	+0.045	<.001	<.001	3	7
BRCA	HDGFL3_S178 →	-0.889	-0.040	.006	.008	3	6
CCRCC	RRM2 →	+0.538	+0.087	<.001	.002	3	6
LUAD	CAD_S1859 →	+0.595	+0.065	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006563 vs ASNS — LUAD

Explore this scatter interactively →