L-serine metabolic process

Across TCGA patient cohorts, RNA activity of the L-serine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSPH, SRRM2_S746, and BCL7C_S122, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine metabolic process activity versus PSPH in HNSC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSPH →	+0.485	+0.092	<.001	<.001	3	4
BRCA	SRRM2_S746 →	-1.234	-0.254	<.001	<.001	3	3
OV	BCL7C_S122 →	-1.884	-0.292	<.001	<.001	3	3
OV	U2SURP_S485 →	-1.251	-0.239	<.001	<.001	3	3
GBM	VCPIP1_S1198 →	-0.367	-0.112	<.001	.001	3	3
UCEC	REPS1_S540 →	-0.727	-0.157	.001	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006563 vs PSPH — HNSC

Explore this scatter interactively →