L-serine metabolic process

Across TCGA cell cohorts, RNA activity of the L-serine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHGDH, OASL, and AARS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine metabolic process activity versus PHGDH in CNS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PHGDH →	+1.958	+0.419	<.001	<.001	3	9
BLOOD_Lymphoma	OASL →	-2.886	-0.294	<.001	<.001	3	6
LUNG_NSCLC_LUAD	AARS1 →	+1.107	+0.240	.001	.001	3	6
BONE	CLTB →	-1.648	-0.361	.001	.003	3	6
OESOPHAGUS	CBX2 →	+1.307	+0.240	<.001	.006	3	6
SKIN	CD9 →	-1.907	-0.266	.009	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006563 vs PHGDH — CNS

Explore this scatter interactively →