Proline metabolic process

Across TCGA patient cohorts, RNA activity of the Proline metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PYCR3, PYCR2, and SCRIB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline metabolic process activity versus PYCR3 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PYCR3 →	+0.330	+0.079	<.001	<.001	3	8
UCEC	PYCR2 →	+0.636	+0.112	<.001	.001	3	8
LUAD	SCRIB →	+0.284	+0.060	<.001	.001	3	7
CCRCC	TACO1 →	+0.292	+0.060	.001	.002	3	7
LSCC	DDX28 →	+0.382	+0.065	.003	.003	3	7
COAD	DNAJA3 →	+0.404	+0.067	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006560 vs PYCR3 — COAD

Explore this scatter interactively →