Proline metabolic process

Across TCGA cell cohorts, RNA activity of the Proline metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBL3, HAUS7, and TSR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline metabolic process activity versus TBL3 in BONE (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TBL3 →	-0.843	-0.470	.006	.001	3	5
BLOOD_Myeloma	HAUS7 →	-1.290	-0.471	.002	.008	2	6
OVARY	TSR1 →	-1.127	-0.363	.005	.009	3	4
BREAST	TAX1BP3 →	-0.957	-0.260	.005	.002	3	4
STOMACH	TPGS1 →	-1.848	-0.439	.001	.004	3	4
STOMACH	PA2G4 →	-0.850	-0.346	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006560 vs TBL3 — BONE

Explore this scatter interactively →