L-phenylalanine metabolic process

Across TCGA patient cohorts, RNA activity of the L-phenylalanine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO46, PRR19, and AKR1B10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-phenylalanine metabolic process activity versus FBXO46 in UCEC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO46 →	-0.366	-0.055	.003	.006	3	5
UCEC	PRR19 →	-0.473	-0.102	.001	<.001	3	5
LUAD	AKR1B10 →	+1.555	+0.111	.001	<.001	3	5
GBM	LINC01480 →	+0.845	+0.113	<.001	<.001	3	5
CCRCC	CDCA2 →	-0.907	-0.183	<.001	<.001	3	5
GBM	TBXAS1 →	+0.808	+0.148	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006558 vs FBXO46 — UCEC

Explore this scatter interactively →