L-phenylalanine metabolic process

Across TCGA cell cohorts, RNA activity of the L-phenylalanine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAH, CTXND1, and SCD5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-phenylalanine metabolic process activity versus FAH in BLOOD_Leukemia (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAH →	+1.213	+1.454	.001	<.001	3	6
BLOOD_Lymphoma	CTXND1 →	+0.071	+1.354	.003	<.001	3	6
BLOOD_Leukemia	SCD5 →	-2.449	-1.301	<.001	<.001	3	5
BLOOD_Lymphoma	SLC44A2 →	-2.518	-1.708	<.001	<.001	3	5
BREAST	CBX3 →	-0.728	-1.643	.002	<.001	3	4
BLOOD_Lymphoma	ELL2 →	+3.035	+1.430	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006558 vs FAH — BLOOD_Leukemia

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