Methionine metabolic process

Across TCGA patient cohorts, RNA activity of the Methionine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL10, ACTG1P10, and PVT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Methionine metabolic process activity versus MRPL10 in LSCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRPL10 →	-0.284	-0.084	.003	.005	3	3
COAD	ACTG1P10 →	-0.337	-0.158	.001	.001	3	3
COAD	PVT1 →	-0.249	-0.141	.003	<.001	3	3
UCEC	GID8 →	-0.358	-0.181	.004	<.001	3	3
PDAC	HDAC5 →	-0.193	-0.088	.003	.006	3	3
UCEC	GTF3C2 →	-0.282	-0.163	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006555 vs MRPL10 — LSCC

Explore this scatter interactively →